In this film, Dr Joff Lacey aims to uncover why antibiotic resistance has become such a huge and real threat across the world. He sees first-hand how rising resistance is already affecting patients in the hospitals of the UK; how cattle farmers are exacerbating the problem; why the hunt for new antibiotics is taking researchers to the caves of South Dakota; and how a new diagnostic tool is helping identify drug-resistant TB in the townships of South Africa.

Joff is on a global journey to explore the terrifying prospect that this era of antibiotics is coming to an end - and what is being done globally to try and combat it.